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toxidrome

Protoanemonin toxidrome

botanicals

definition

protoanemonin toxidrome

the following toxicity information is largely derived from poisonings, overdoses and research on isolated constituents; used with appropriate clinical judgment and cautious prescribing, herbs are safe and efficacious

plants included:

» Anemone pulsatilla

• Protanemonin toxidrome: burning sensation in oropharynx followed by gastrointestinal and cardiovascular effects. Gastrointestinal irritation includes: hematemesis, vomiting, diarrhea, feeling of tightness and constriction in chest (Ellingwood, p. 149; AMA, p. 32)

• cardiovascular effects: bradycardia, arrhythmia, severe cardiorespiratory collapse

• mild cerebral irritant effects: giddiness, vertigo, syncope; moderate to severe causes may result in dyspnea, mydriasis, weakness, stupor, sensory and motor depression, paralysis, convulsions and coma

• renal effects: polyuria, followed by hematuria and lower pain back/CVA tenderness with percussion; oliguria indicates damage has occurred (AMA, p. 32; Ellis, p. 71; Levy and Primack, p. 110; Poisindex)

footnotes

Ellingwood, F. 1898. American Materia Medica, Therapeutics, and Pharmacognosy. Portland, OR: Eclectic Medical Publications.

Ellis, M.D. 1975. Dangerous Plants, Snakes, Arthropods, And Marine Life. Hamilton, IL: Drug Intelligence Publications, Inc.

Lampe, K.F., and McAnn, M.A. 1985. AMA Handbook of Poisonous and Injurious Plants. Chicago: American Medical Association.

Levy, C.K.; and Primack, R.B. 1984. A Field Guide to Poisonous Plants and Mushrooms of North America. The Stephen Green Press.

ilton, IL: Drug Intelligence Publications, Inc.

Lampe, K.F., and McAnn, M.A. 1985. AMA Handbook of Poisonous and Injurious Plants. Chicago: American Medical Association.

Levy, C.K.; and Primack, R.B. 1984. A Field Guide to Poisonous Plants and Mushrooms of North America. The Stephen Green Press.

Stephen Green Press.